CAMI has just added a new nuclear imaging modality; a positron emission tomography and x-ray computed tomography (PET/CT)imaging system. CAMI was the first facility to offer nuclear imaging for small animals at Northwestern when single-photon emission computed tomography (SPECT/CT) was added in August 2014. Both the PET/CT and SPECT/CT scanners offer sub-millimeter resolution with high sensitivity, utilizing state-of-the-art hardware and software. These preclinical instruments are smaller versions of those used in the clinic, allowing researchers at CAMI to translate preclinical findings directly to patients. The addition of these imaging modalities to CAMI’s suite of MRI and IVIS instruments allows CAMI to provide unparalleled service in translational medicine, therapeutics, and diagnostics. The data generated by CAMI’s nuclear imaging instruments will provide investigators with quantitative, noninvasive and longitudinal measurements that address the technological needs and enhance the advancements of a wide range of biomedical research projects ongoing at Northwestern University. Nuclear imaging is not is not only more sensitive than most traditional animal studies, such as biodistribution and toxicity studies, it also requires fewer animals to obtain significant results and is more clinically relevant. Please contact CAMI’s managing director, Chad Haney (chad.haney@northwestern.edu), to discuss how preclinical imaging can transform your research.