Equipment
- Mediso NanoScan PET/CT system
Example Applications
- Use a radiolabeled antibody to detect an early marker of Alzheimer’s Disease.
- Track bone regeneration in the presence of a hydrogel scaffold.
- Measure degradation over time of implanted bioresorbable devices.
Recent PET/CT publications
The Therapeutic and Diagnostic Potential of Amyloid β Oligomers Selective Antibodies to Treat Alzheimer’s Disease
Viola KL, .. Klein WL. Frontiers in Neuroscience. 2022;15(1798). Continue Reading The Therapeutic and Diagnostic Potential of Amyloid β Oligomers Selective Antibodies to Treat Alzheimer’s Disease
Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues
Yang Q, .. Rogers JA. Nature materials. 2021;20(11):1559-70. Continue Reading Photocurable bioresorbable adhesives as functional interfaces between flexible bioelectronic devices and soft biological tissues
Fully implantable and bioresorbable cardiac pacemakers without leads or batteries
Choi YS, .. Rogers JA. Nat Biotechnol. 2021;39(10):1228-38 Continue Reading Fully implantable and bioresorbable cardiac pacemakers without leads or batteries
Technical Details
PET/CT
In April 2015, a Mediso nanoScan Positron Emission Tomography (PET) scanner was installed in CAMI. The nanoScan PET/CT has the highest spatial resolution on the market at 0.3 mm. The nanoScan’s 11 cm bore size is suitable for imaging mice and rats. The LYSO:Ce based detectors have > 6% sensitivity with image quantification accuracy over 97%. Attenuation correction is accomplished with the CT module, which can image at 10 µm resolution. The GPU based reconstruction is performed during acquisition, with reconstruction often finishing only minutes after acquisition is completed. Therefore the system is capable of high throughput without compromising image quality.